I’m working on a Anatomy exercise and need support.
Muscle Tissue choose ONE of the following diseases in order to answer the following questions
1. Duchenne muscular dystrophy (DMD)
•Caused by a mutation in the gene for dystrophin
•Dystrophin helps connect the cytoskeleton of a cell to the basal lamina – main issue
•Two extra side effect are that excess calcium enters the cell and the mitochondria burst
•Caused by external damage to the muscle
•Leads to the breakdown of muscle fibers
•Two extra side effects are that excess calcium and continuous muscle contractions
3. Myosin Storage
•Caused by a mutation in the gene for MYH7
•Leads to an accumulation of myosin
•Two extra side effects are muscular weakness and spasms
Use the information about your disease to answer the following questions:
1. Using the two images below, or an image of your choice, explain what physical differences would occur in a muscle cell due to this disease.
2. Would this disease alter how your muscles can contract? List the events that occur during a contraction using the sliding filament model and indicate where, if anywhere, this disease would cause a problem and how. If it doesn’t, why not?
3. Would this disease effect one type of muscle fiber (Types I/IIa/IIb) more than the others? Why or why not?